Adaptation of Arginine Synthesis among Uropathogenic Branches of the Escherichia coli Phylogeny Reveals Adjustment to the Urinary Tract Habitat

ABSTRACT Urinary tract infections (UTIs) are predominantly caused by uropathogenic Escherichia coli (UPEC).UPEC pathogenesis requires passage through a severe population bottleneck involving intracellular bacterial communities (IBCs) that are clonal expansions of a single invading UPEC bacterium in a urothelial superficial facet Kitchen Tongs cell.

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